Endocrine Abstracts

Objective: Pregnancy-related osteoporosis is a rare disorder with potentially severe complications. There is lack of clinical practice guidelines due to low incidence of this disease and few published cases.Material and methods: We present eight cases of pregnancy-related osteoporosis in women aged between 28–42 years. Six of them were diagnosed between 1 month and 3 years postpartum and two were diagnosed in the third trimester of pregnancy. Most o...

Introduction: The improvement of vitamin D status is necessary to overcome an impaired calcium-phosphorus metabolism and disturbances in other tissues functioning; safety of medical intervention should include analysis of metabolic changes.Material and methods: Twenty four apparently healthy volunteers 24.9±2 year were included in the study: Group 1 (11/24) with blood serum levels of 25(OH)D <10 ng/ml and Group 2 (13/24) with 25(OH)D levels 10&#...

Objective: To study the effect of neurohormones kisspeptin and neurokinin B on the indices of calcium-phosphate and electrolyte metabolism in patients with neuroendocrine pathology.Material and Methods: Eighty-two female patients were included in this pilot study divided into 2 groups: ‘Cushing’s disease’ group (n=51) and ‘Acromegaly’ group (n=31). Median age was 33 years [27; 38] in ‘Cushing’s disease...

Background: ACTH-ectopic syndrome is a rare cause of endogenous hypercortisolism and may pose serious difficulties in topical diagnosis.Case description: Clinical features of hypercortisolism manifested at the age of 18 years (2012). A year later he was referred to an endocrinologist: ACTH 113 pg/ml (0–46), cortisol in 24-h urine 2915 μg/day (4.3–176), 1 mg DX test cortisol 1020 nmol/l, 8 mg DX test 764 nmol/l, intact pituitary MRI with co...

Objective: Tumor-induced osteomalacia is a rare paraneoplastic syndrome in which fibroblast growth factor 23 (FGF-23) hyperproduction by tumor causes renal phosphate wasting, severe hypophosphatemia and osteomalacia. Localization of the tumor can be a major diagnostic challenge.Material and methods: We present a clinical case concerning a 62-year old woman previously diagnosed with hypophosphatemic osteomalacia, with a slight improvement of clinical and ...